Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Tom Matukewicz
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | L | 47-21 |
| NCAAF | 2020/10/30 23:00 | SE Missouri St v SO Illinois | L | 17-20 |
| NCAAF | 2019/08/29 23:30 | SO Illinois v SE Missouri St | W | 26-44 |
| NCAAF | 2018/09/15 23:00 | SE Missouri St v SO Illinois | W | 48-44 |
| NCAAF | 2017/09/16 23:00 | SE Missouri St v SO Illinois | L | 17-35 |
| NCAAF | 2022/09/03 18:00 | SE Missouri St v Щат Айова | L | 10-42 |
| NCAAF | 2021/11/20 19:00 | Тенеси Мартин v SE Missouri St | W | 14-31 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Мъти Стейт | L | 10-28 |
| NCAAF | 2021/10/30 18:00 | Ийстърн Илинойс v SE Missouri St | W | 15-38 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Тенеси Мартин | L | 30-38 |
| NCAAF | 2021/10/16 19:00 | Мъти Стейт v SE Missouri St | L | 32-31 |
| NCAAF | 2021/10/09 20:00 | SE Missouri St v Остин Пий | W | 30-14 |
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Тениси Тек | L | 17-28 |
| NCAAF | 2022/09/03 23:00 | SO Illinois v Инкарнате Уърд | L | 29-64 |
| NCAAF | 2021/12/04 20:30 | SO Illinois v Щат Северна Дакота | L | 7-38 |
| NCAAF | 2021/11/27 23:00 | SO Illinois v Саут Дакота | W | 22-10 |
| NCAAF | 2021/11/20 18:00 | Йънгстаун State v SO Illinois | L | 35-18 |
| NCAAF | 2021/11/13 18:00 | SO Illinois v Индианс Стейт | W | 47-21 |
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | L | 38-28 |
| NCAAF | 2021/10/30 21:00 | SO Illinois v Нордърн Айова | L | 16-23 |
| NCAAF | 2021/10/16 19:00 | Северна Дакота v SO Illinois | W | 28-31 |