Stadium: Dave Wolk Stadium Round: 1
| NCAAF | 2022/09/03 16:00 | Plymouth State Panthers v Castleton Spartans | L | 20-7 |
| NCAAF | 2021/09/04 17:00 | Castleton Spartans v Plymouth State Panthers | W | 13-0 |
| NCAAF | 2019/09/07 17:00 | Castleton Spartans v Plymouth State Panthers | L | 17-23 |
| NCAAF | 2018/09/01 17:00 | Castleton Spartans v Plymouth State Panthers | L | 0-38 |
| NCAAF | 2022/11/12 19:00 | Anna Maria Amcats v Castleton Spartans | L | 27-26 |
| NCAAF | 2022/10/29 16:00 | Castleton Spartans v Alfred State Pioneers | W | 37-13 |
| NCAAF | 2022/10/22 16:00 | Keystone Giants v Castleton Spartans | W | 20-35 |
| NCAAF | 2022/10/15 16:00 | Castleton Spartans v Suny Maritime Privateers | W | 36-33 |
| NCAAF | 2022/10/08 16:00 | Gallaudet Bison v Castleton Spartans | L | 20-17 |
| NCAAF | 2022/10/01 21:00 | Castleton Spartans v Dean Bulldogs | W | 39-0 |
| NCAAF | 2022/09/24 16:00 | Castleton Spartans v St Lawrence Saints | L | 6-34 |
| NCAAF | 2022/09/17 18:00 | Norwich Cadets v Castleton Spartans | L | 26-21 |
| NCAAF | 2022/11/12 17:00 | Plymouth State Panthers v Umass Dartmouth Corsairs | L | 21-46 |
| NCAAF | 2022/11/05 16:00 | Massachusetts Maritime Buccaneers v Plymouth State Panthers | W | 7-21 |
| NCAAF | 2022/10/29 16:00 | Plymouth State Panthers v Westfield State Owls | W | 31-22 |
| NCAAF | 2022/10/22 16:00 | Worcester State Lancers v Plymouth State Panthers | W | 21-56 |
| NCAAF | 2022/10/15 16:00 | Fitchburg State Falcons v Plymouth State Panthers | W | 7-42 |
| NCAAF | 2022/10/08 17:00 | Plymouth State Panthers v Western Connecticut Colonials | L | 27-34 |
| NCAAF | 2022/10/01 16:00 | Framingham State Rams v Plymouth State Panthers | W | 9-14 |
| NCAAF | 2022/09/17 16:00 | Plymouth State Panthers v Bridgewater State Bears | W | 41-34 |