| NCAAF | 11/11 18:00 | 1 | Monmouth Scots v Knox Prairie Fire | L | 42-7 | |
| NCAAF | 11/04 18:00 | 1 | Knox Prairie Fire v Lawrence Vikings | W | 48-28 | |
| NCAAF | 10/28 18:00 | 1 | Knox Prairie Fire v Cornell Rams | L | 21-28 | |
| NCAAF | 10/21 18:00 | 1 | Grinnell Pioneers v Knox Prairie Fire | W | 7-14 | |
| NCAAF | 10/14 18:00 | 1 | Illinois College Blueboys v Knox Prairie Fire | L | 61-7 | |
| NCAAF | 10/07 18:00 | 1 | Knox Prairie Fire v Ripon Red Hawks | L | 3-10 | |
| NCAAF | 09/30 19:00 | 1 | Knox Prairie Fire v Lake Forest Foresters | L | 0-50 | |
| NCAAF | 09/16 19:00 | 1 | Chicago Maroons v Knox Prairie Fire | L | 63-0 | |
| NCAAF | 09/09 18:00 | 1 | Knox Prairie Fire v Beloit Buccaneers | W | 31-14 | |
| NCAAF | 09/02 23:00 | 1 | Eureka Red Devils v Knox Prairie Fire | L | 41-16 | |
| NCAAF | 11/12 18:00 | 1 | Knox Prairie Fire v Monmouth Scots | L | 0-56 | |
| NCAAF | 11/05 18:00 | 1 | Cornell Rams v Knox Prairie Fire | W | 27-31 | |
| NCAAF | 10/29 18:00 | 1 | Lawrence Vikings v Knox Prairie Fire | W | 0-35 | |
| NCAAF | 10/22 18:00 | 1 | Knox Prairie Fire v Illinois College Blueboys | L | 10-20 | |
| NCAAF | 10/15 18:00 | 1 | Knox Prairie Fire v Grinnell Pioneers | W | 28-7 | |
| NCAAF | 10/08 18:00 | 1 | Beloit Buccaneers v Knox Prairie Fire | W | 25-34 | |
| NCAAF | 10/01 18:00 | 1 | Knox Prairie Fire v Chicago Maroons | L | 14-50 | |
| NCAAF | 09/17 19:00 | 1 | Lake Forest Foresters v Knox Prairie Fire | L | 48-14 | |
| NCAAF | 09/10 23:00 | 1 | Ripon Red Hawks v Knox Prairie Fire | L | 33-6 | |
| NCAAF | 09/03 18:00 | 1 | Knox Prairie Fire v Westminster Blue Jays | W | 26-0 | |
| NCAAF | 11/13 18:00 | 1 | Monmouth Scots v Knox Prairie Fire | L | 38-7 | |
| NCAAF | 11/06 18:00 | 1 | Knox Prairie Fire v Cornell Rams | L | 34-35 | |
| NCAAF | 10/30 18:00 | 1 | Knox Prairie Fire v Lawrence Vikings | W | 56-28 | |
| NCAAF | 10/23 18:00 | 1 | Illinois College Blueboys v Knox Prairie Fire | L | 27-20 | |
| NCAAF | 10/16 18:00 | 1 | Grinnell Pioneers v Knox Prairie Fire | W | 28-49 | |
| NCAAF | 10/09 18:00 | 1 | Knox Prairie Fire v Beloit Buccaneers | W | 42-0 | |
| NCAAF | 10/02 19:00 | 1 | Chicago Maroons v Knox Prairie Fire | L | 45-10 | |
| NCAAF | 09/18 19:00 | 1 | Knox Prairie Fire v Lake Forest Foresters | L | 10-41 | |
| NCAAF | 09/11 18:00 | 1 | Knox Prairie Fire v Ripon Red Hawks | L | 14-20 | |
| NCAAF | 11/09 19:00 | 1 | Monmouth Scots v Knox Prairie Fire | L | 31-3 |